PNC-27 5mg

PNC-27 is a synthetic peptide composed of 27 amino acids, designed as a derivative of the α-helical region of the tumor-suppressor protein p53 (ASPP2). It has been explored for its potential to affect the growth and survival of certain cancer cells.

Early findings indicate that PNC-27 may interact specifically with cancer cell membranes while leaving healthy cells largely unaffected. The peptide was first developed in 2000 during research related to immunodeficiency (HIV) and was found to bind to HDM2, a protein commonly overexpressed on the membranes of malignant cells. Unlike many experimental compounds that trigger apoptosis, PNC-27 appears to disrupt cancer cells through necrosis. This is thought to occur when the peptide forms pores in the cellular membrane, compromising its integrity and leading to ion imbalance, leakage of cellular contents, and eventual cell death.