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| Quantity: | 5mg, 10mg |
|---|---|
| Unit: | 1 vial |
| Contents: | AOD9604 |
| Form/Appearance: | Lyophilized/Powder |
| Peptide Purity: | 99% |
| Sequence: | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Disulfide bridge Cys7-Cys14 |
| Molecular Mass: | 1815.12 g/mol |
| Solubility: | Sterile / Bacteriostatic water |
| Synonyms: | AOD 9604 |
FAQs
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Size: 10mg
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Form: Lyophilized powder
Purity: >99%
Semax is an interesting nootropic that can capture the attention of researchers, health professionals, and enthusiasts alike. It was originally developed in Russia back in the 1980s and 1990s. Nowadays, Semax is believed to enhance a range of cognitive and neuroprotective properties.
Many know this peptide by its trade name, such as Semaxum, and it has been extensively researched by institutions such as the Institute of Molecular Genetics of the Russian Academy of Science.
What is Semax?
Semax is a peptide best known for its neurogenic, neuroprotective, and nootropic properties. It was developed based on the molecular structure of ACTH or adrenocorticotropic hormone. Preliminary studies in small-scale human trials, animals, and cells indicate potential benefits of Semax use.
In the U.S. and multiple countries around the world, this component is the basis for a number of medicines that are used in clinical practices for the treatment of optic nerve atrophy, dys-circulatory encephalopathy, and ischemic brain stroke.
Potential benefits
Some of the benefits Semax may include:
- Increased short-term memory and attention
- Better non-proliferative diabetic neuropathy
- Can assist during recovery from hypoxia/stroke
- Can help with glaucoma optic neuropathy
- May act as an analgesic
- It may help in treating ADHD
- It may help protect the brain from various types of damage and stress
How Does Semax Work?
Semax increases BDNF or brain-derived neurotrophic factor. BDNF is one of the most active neurotrophins, which help control and stimulate neurogenesis, creating new neurons in the brain. This component helps support neuroplasticity, allowing nerve cells in the brain to adapt to new situations and recover from injury.
Additionally, BDNF encourages the survival of existing neurons and supports the growth, creation, and regeneration of new synapses and neurons.
This nootropic also helps minimize the breakdown of enkephalins. Enkephalins are mostly involved in reducing inflammation, decreasing pain, boosting immune cell activity, and preventing cancer cell growth.
They also play a role in pain, emotional behavior, learning, and memory. Balanced enkephalins are necessary to maintain normal brain function. Therefore, researchers are led to believe that Semax may potentially relieve pain. However, more research is needed to confirm the preliminary findings.
References:
Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. doi: 10.1186/1471-2164-15-228. PMID: 24661604; PMCID: PMC3987924.
https://www.sciencedirect.com/science/article/abs/pii/S0306987706005391
Gusev, E. & Martinov, Michail & Kostenko, E. & Petrova, Lyudmila & Bobyreva, S.. (2018). The efficacy of semax in the tretament of patients at different stages of ischemic stroke. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 118. 61. 10.17116/jnevro20181183261-68.
Size: 2mg / 5mg
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Form: Lyophilized powder
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Size: 5mg / 10mg
Contents: Retatrutide
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Melanotan 2 is a synthetic version of human alpha-melanocyte stimulating hormone and acts as a non selective melanocortin-receptor agonist. It was mainly developed as a sunless tanning option, but some clinical studies showed it also causes spontaneous penile erections, as well as general sexual stimulation.
Some of the other “side effects” researchers noticed were reduction in compulsive behavior, reduced glucagon production, hunger suppression and even some limited addiction control.
Melanotan 2 Effects On Autism
There is some additional recent clinical research suggesting there might be a link between Mealnotan 2 and autism. Of course, melanotan treatment cannot reverse autism, sadly, but it may act on some aspects of this disorder and make it more manageable.
In mouse model studies researchers recorded that MT2 stimulated oxytocin release, which had the potential to reduce (in some cases counteract) common ASD behaviors – behaviors that include:
- Hand clapping
- Bouncing on toes
- Body rocking
- Holding body parts in unusual positions
- Repeating vocalizations etc.
Epitalon is a synthetic peptide, made up of 4 amino acids – alanine, glycine, glutamic and aspartic acid. It’s based on a natural peptide epithalamion, commonly extracted from the pineal gland. Some earlier studies showed epitalon’s antioxidant potential, so more recent ones started focusing on its anti-aging potential.
Recent studies also showed its potential in regulating DNA changes, treating infectious diseases… even addressing some types of cancer.
Anti Aging Properties
The fact that epitalon is epithalamin’s extract, means it has the ability to eliminate free radicals that cause tissue damage. A particular research study on flies and mice showed that, after epitalon’s administration, fruit flies mortality rate dropped by a whopping 52%, while the mortality rate in rats dropped by 27%, as compared to the control studies. What researchers learned from this study was that regular epitalon administration stimulated the synthesis and secretion of melatonin, which inhibits free radical production and its subsequent damage.
There was another in vitro study on human somatic non-reproductive cells suggesting that epitalon peptide affects telomerase activity. Telomerase is an enzyme present in cells, allowing them to live longer. So, essentially, this study showed the researchers that this therapy leads to the prolonged cell lifespan. Of course, we still need full scale human studies to see the full extent of prolonged cell lifespan.
DNA Effects
Epitalon also interacts with DNA gene expression, allowing it to have an indirect effect on a whole host of potential bodily functions – from immune system, to skin, tendon and connective tissue repair.
This essentially allows epitalon peptide therapy to have a dual potential effect – on the one hand, it strengthens the immune system and protects the body from outside factors, and on the other, it allows the body to repair and regenerate its structures on its own.
Skin Cell Regeneration
We already talked about epitalon’s effect on DNA and genes. This effect extends to the fibroblast producing and maintaining MMP2. Interestingly, this peptide also affects other skin components, such as collagen and elastin.
Of course, we still have yet to see definitive human studies, but animal ones showed promising results. Young and old rats exposed to epitalon showed skin fibroblast proliferation of 29 and up to 45%. Not only that, epitalon also activates enzymes that slow down programmed cell death.
References:
Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY). 2022 Apr 12;14(7):3191-3202. doi: 10.18632/aging.204007. Epub 2022 Apr 12. PMID: 35413689; PMCID: PMC9037278.
Anisimov VN, Mylnikov SV, Khavinson VK. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998 Jun 15;103(2):123-32. doi: 10.1016/s0047-6374(98)00034-7. PMID: 9701766.
Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. PMID: 12937682.
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