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Epithalon 20mg/50mg $90.00 – $200.00
Epitalon is a synthetic peptide, made up of 4 amino acids – alanine, glycine, glutamic and aspartic acid. It’s based on a natural peptide epithalamion, commonly extracted from the pineal gland. Some earlier studies showed epitalon’s antioxidant potential, so more recent ones started focusing on its anti-aging potential.
Recent studies also showed its potential in regulating DNA changes, treating infectious diseases… even addressing some types of cancer.
Anti Aging Properties
The fact that epitalon is epithalamin’s extract, means it has the ability to eliminate free radicals that cause tissue damage. A particular research study on flies and mice showed that, after epitalon’s administration, fruit flies mortality rate dropped by a whopping 52%, while the mortality rate in rats dropped by 27%, as compared to the control studies. What researchers learned from this study was that regular epitalon administration stimulated the synthesis and secretion of melatonin, which inhibits free radical production and its subsequent damage.
There was another in vitro study on human somatic non-reproductive cells suggesting that epitalon peptide affects telomerase activity. Telomerase is an enzyme present in cells, allowing them to live longer. So, essentially, this study showed the researchers that this therapy leads to the prolonged cell lifespan. Of course, we still need full scale human studies to see the full extent of prolonged cell lifespan.
DNA Effects
Epitalon also interacts with DNA gene expression, allowing it to have an indirect effect on a whole host of potential bodily functions – from immune system, to skin, tendon and connective tissue repair.
This essentially allows epitalon peptide therapy to have a dual potential effect – on the one hand, it strengthens the immune system and protects the body from outside factors, and on the other, it allows the body to repair and regenerate its structures on its own.
Skin Cell Regeneration
We already talked about epitalon’s effect on DNA and genes. This effect extends to the fibroblast producing and maintaining MMP2. Interestingly, this peptide also affects other skin components, such as collagen and elastin.
Of course, we still have yet to see definitive human studies, but animal ones showed promising results. Young and old rats exposed to epitalon showed skin fibroblast proliferation of 29 and up to 45%. Not only that, epitalon also activates enzymes that slow down programmed cell death.
References:
Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY). 2022 Apr 12;14(7):3191-3202. doi: 10.18632/aging.204007. Epub 2022 Apr 12. PMID: 35413689; PMCID: PMC9037278.
Anisimov VN, Mylnikov SV, Khavinson VK. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998 Jun 15;103(2):123-32. doi: 10.1016/s0047-6374(98)00034-7. PMID: 9701766.
Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. PMID: 12937682.
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Sermorelin and Ipamorelin Peptide Blend $100.00
In medical circles, Sermorelin and Ipamorelin are often mentioned as a fountain of youth. While no single ingredient has the ability to reverse the aging process and stop our cells from deteriorating, this blend has shown promising results in a laboratory setting.
Both ingredients are human growth hormone-releasing peptides that stimulate the pituitary gland. Based on the studies conducted on animals, they are believed to preserve youthful anatomy and psychology.
What is Sermorelin?
Sermorelin is a synthetically made version of GHRH, or growth hormone-releasing hormone, which is responsible for promoting the natural release of growth hormone. It works by binding GHRH to the anterior part of the pituitary gland, stimulating the natural production of GH.
When doing research on rats and primates, scientists came up with the following benefits:
Sermorelin was able to:
- Increase muscles
- Increase lean body mass
- Decrease body fat
- Boost recovery from training sessions and injuries
- Enhance joint health and flexibility
- Improve overall wellness and health
What is Ipamorelin?
As the previous compound, Ipamorelin stimulates the release of growth hormone while reducing the release of somatostatin. Based on laboratory research, Ipamorelin has demonstrated the following benefits in the domain of anti-aging:
- Increased bone density
- Loss of body fat in obese adults
- Increased muscle mass
- Better immune system
- Improved cellular protein synthesis
Sermorelin and Ipamorelin Blend
These two peptides are often combined because they are believed to slow down aging processes, increase muscle mass, minimize inflammation, decrease fat mass, and health the gut. Research in pigs indicates that Sermorelin minimizes cell death of cardiomyocytes, boosts healing after cardiac injury, improves the collateral blood vessels, and reduces inflammation.
In addition to this, the administration of ghrelin analogues and ghrelin has been shown to lower abnormal heartbeats.
It has also been found that Sermorelin and Ipamorelin can benefit the central nervous system and boost sleep quality in animal models.
References:
Bagno LL, Kanashiro-Takeuchi RM, Suncion VY, Golpanian S, Karantalis V, Wolf A, Wang B, Premer C, Balkan W, Rodriguez J, Valdes D, Rosado M, Block NL, Goldstein P, Morales A, Cai RZ, Sha W, Schally AV, Hare JM. Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. J Am Heart Assoc. 2015 Mar 31;4(4):e001464. doi: 10.1161/JAHA.114.001464. PMID: 25827134; PMCID: PMC4579962.
Kanashiro-Takeuchi RM, Szalontay L, Schally AV, Takeuchi LM, Popovics P, Jaszberenyi M, Vidaurre I, Zarandi M, Cai RZ, Block NL, Hare JM, Rick FG. New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget. 2015;6(12):9728-39. doi: 10.18632/oncotarget.3303. PMID: 25797248; PMCID: PMC4496393.
Tokudome T, Otani K, Miyazato M, Kangawa K. Ghrelin and the heart. Peptides. 2019 Jan;111:42-46. doi: 10.1016/j.peptides.2018.05.006. Epub 2018 May 20. PMID: 29791869.
Shepherd BS, Johnson JK, Silverstein JT, Parhar IS, Vijayan MM, McGuire A, Weber GM. Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol A Mol Integr Physiol. 2007 Mar;146(3):390-9. doi: 10.1016/j.cbpa.2006.11.004. Epub 2006 Nov 24. PMID: 17240179.
