If you’re a peptide researcher (or plan on becoming one), you should know the difference between CJC-1295 and CJC-1295 DAC. CJC-1295 DAC features an additional component at the end of the peptide chain, also known as a drug affinity complex or DAC.

This small fragment changes the peptide’s functionality and extends its half-life to six to eight days. It might have a prolonged effect of up to two weeks.

Below, we will showcase the main similarities and differences between these two peptides, including their properties, characteristics, and mechanism of action.

What is CJC-1295 DAC peptide?

This peptide resembles the regular CJC-1925 since it is a modified form of natural GHGR (1-29). However, this one differs from CJC-1925. It has an additional molecule known as a “drug affinity complex.”

DAC features a couple of oxygen and nitrogen atoms connected by chemical bonds. According to some findings, this small number of atoms could significantly impact peptide breakdown rate and its use in the body.

What is CJC-1295 Peptide?

This peptide is also known as “modified growth hormone releasing factor (1-29)”, “ModGRF 1-29”, or “Modified GRF (1-29).” You may also encounter the name “CJC-1295, without DAC.”

All these names imply a specific peptide molecule containing a short amino acid chain. As many studies have indicated, this peptide may boost growth hormones in the bloodstream.

Growth hormone may have a significant role in several vital internal activities. It could facilitate cellular reproduction, repair, and growth, help with tissue repair, improve muscle cell development, support skin cells, and other functions.

While the body naturally produces growth hormone, this production tends to naturally decrease. According to some research done in laboratory settings, CJC-1295 may encourage the natural production of growth hormone, increasing its levels, which could lead to quicker repair, fat cell burn, and muscle cell growth.

Differences between CJC-1295 DAC and CJC-1295

As research studies have outlined, here are some fundamental differences between these two peptides.

Half-life

The main distinction lies in their half-lives. CJC-1295 is thought to mimic the body’s natural peptide. The endogenous GHRH has a short half-life of just a couple of minutes. Similarly, CJC-1295 has a brief half-life of around half an hour.

Regarding the second peptide, the additional DAC could significantly alter the organism’s peptide use. Researchers believe that DAC offers a peptide, a lysine linker, which could protect and prevent it from degrading.

Moreover, the DAC component could extend the half-life of this peptide to about six to eight days.

Properties of CJC-1295 DAC peptide

It is believed that CJC-1295 DAC boosts growth hormone levels in the bloodstream. Additionally, several studies suggest the following:

• Scientists and researchers need to focus their attention to studying the potential of growth hormones on growth and muscle recovery.
• Growth hormone may help convert fatty tissue into energy.
• Growth hormones are linked with collagen production in the skin, which means this peptide may also help with skin regeneration and skin cell development.
• CJC-1295 DAC may positively impact sleep patterns.
• Growth hormone is essential for tissue regeneration and helps the organism recover from damage.

References:

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.

Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A. Frohman, Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805,